Structure 2 Function Project.

Functions of many genes in microbial genomes are not understood. In some bacteria “hypothetical" genes constitute more than 40% of all the genes. The Structure 2 Function is a structural genomics project that aims to increase knowledge about these genes by solving their 3D structure. Our group is a principle bioinformatics group involved in the project. We are responsible for analysis and prioritizing selection of targets, as well on going computation support for crystallography and NMR groups.

Snps3D

Many human diseases are caused by single nucleotide polymorphisms (SNP). The SNP3D website aims to combine results of our prediction models of deleterious mutations with knowledge of protein-protein interactions, homology models of protein structures, and sequence conservation profiles

Alternative Splicing Project

It has been recently discovered that 35-75% of all human genes are alternatively spliced. The Alternative Splicing Project is structural genomic project that seems to determine crystal structure of alternative transcripts. This website was developed to help in selection and analysis of targets for crystallization trials. The site contains information about 3D structure of alternative transcripts, gene structure displays, predictions novel isoforms and many other useful tools.

Forcasp

The Forcasp is a forum website maintain by our group for benefits of structure prediction community. The aim of the project is to increase communication between predictors and to stimulate discussions about problems that need to be solved in order to achieve high quality models.