SNPS and Diseases
The Biochemical Journal 2009 Oct 23;424(1):15-26.
A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.
Allali-Hassani A, Wasney GA, Chau I, Hong BS, Senisterra G, Loppnau P, Shi Z, Moult J, Edwards AM, Arrowsmith CH, Park HW, Schapira M, Vedadi M. pdf
BMC Bioinformatics. 2006 Mar 22;7:166.
SNPs3D: candidate gene and SNP selection for association studies.
Yue P, Melamud E, Moult J. pdf
J Mol Biol. 2006 Mar 10;356(5):1263-74.
Identification and analysis of deleterious human SNPs.
Yue P, Moult J. pdf
J Mol Biol. 2005 Oct 21;353(2):459-73.
Loss of protein structure stability as a major causative factor in monogenic disease.
Yue P, Li Z, Moult J. pdf
Proteins. 2003 Nov 15;53(3):748-57.
Three-dimensional structural location and molecular functional
effects of missense SNPs in the T cell receptor Vbeta domain.
Wang Z, Moult J. pdf
Hum Mutat. 2001 Apr;17(4):263-70.
SNPs, protein structure, and disease.
Wang Z, Moult J. pdf
Alternative Splicing
Nucleic Acids Res. 2009 August; 37(14): 4862–4872
Structural implication of splicing stochastics
E. Melamud, and J. Moult pdf
Nucleic Acids Res. 2009 August; 37(14): 4873–4886
Stochastic noise in splicing machinery
E. Melamud, and J. Moult pdf
CASP Related
Proteins. 2009 Aug 21;77(S9):1-4 [Epub ahead of print]
Critical assessment of methods of protein structure prediction-Round VIII.
Moult J, Fidelis K, Kryshtafovych A, Rost B, Tramontano A.pdf
Proteins. 2009 Aug 5;77(S9):18-28. [Epub ahead of print]
Evaluation of template-based models in CASP8 with standard measures.
Cozzetto D, Kryshtafovych A, Fidelis K, Moult J, Rost B, Tramontano A. pdf
Proteins. 2009 Aug 5;77(S9):217-228. [Epub ahead of print]
CASP8 results in context of previous experiments.
Kryshtafovych A, Fidelis K, Moult J. pdf
Nature Reviews. Drug Discovery. 2009 Jun;8(6):455-63.
Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.
Michino M, Abola E; GPCR Dock 2008 participants, Brooks CL 3rd, Dixon JS, Moult J, Stevens RC. pdf
Proteins. 2007 Oct 5;69(S8):3-9.
Critical assessment of methods of protein structure prediction-Round VII.
Moult J, Fidelis K, Kryshtafovych A, Rost B, Hubbard T, Tramontano A. pdf
Proteins. 2007 Oct 5;69(S8):194-207.
Progress from CASP6 to CASP7.
Kryshtafovych A, Fidelis K, Moult J. pdf
Proteins. 2005;61 Suppl 7:225-36.
Progress over the first decade of CASP experiments.
Kryshtafovych A, Venclovas C, Fidelis K, Moult J. pdf
Computational Biology
Genome Biol. 2008;9(8):R121. Epub 2008 Aug 3.
Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules.
Hodis E, Prilusky J, Martz E, Silman I, Moult J, Sussman JL. pdf
Philos Trans R Soc Lond B Biol Sci. 2006 Mar 29;361(1467):453-8.
Rigorous performance evaluation in protein structure modelling and implications for computational biology.
Moult J. pdf
Proteins. 2006 Apr 1;63(1):53-64.
Towards computing with proteins.
Unger R, Moult J. pdf
Structural Genomics
Structure. 2009 Feb 13;17(2):151-9.
Outcome of a workshop on applications of protein models in biomedical research.
Schwede T, Sali A, Honig B, Levitt M, Berman HM, Jones D, Brenner SE, Burley SK, Das R, Dokholyan NV, Dunbrack RL Jr, Fidelis K, Fiser A, Godzik A, Huang YJ, Humblet C, Jacobson MP, Joachimiak A, Krystek SR Jr, Kortemme T, Kryshtafovych A, Montelione GT, Moult J, Murray D, Sanchez R, Sosnick TR, Standley DM, Stouch T, Vajda S, Vasquez M, Westbrook JD, Wilson IA. pdf
Structure. 2008 Jan;16(1):14-6.
Comparative modeling in structural genomics.
Moult J. pdf
J Mol Biol. 2005 Oct 28;353(3):744-59.
Protein family clustering for structural genomics.
Yan Y, Moult J. pdf
Nat Struct Biol. 2001 Jun;8(6):559-66. Related Articles, Links
Completeness in structural genomics.
Vitkup D, Melamud E, Moult J, Sander C. pdf
Curr Drug Targets Infect Disord. 2002 Dec;2(4):339-53.
Assisting functional assignment for hypothetical Heamophilus
influenzae gene products through structural genomics.
Gilliland GL, Teplyakov A, Obmolova G, Tordova M, Thanki N, Ladner J,
Herzberg O, Lim K, Zhang H, Huang K, Li Z, Tempczyk A, Krajewski W,
Parsons L, Yeh DC, Orban J, Howard AJ, Eisenstein E, F Parsons J, Bonander
N, Fisher KE, Toedt J, Reddy P, Rao CV, Melamud E, Moult J.pdf
Function and Protein Folds
Proteins. 2002 Jan 1;46(1):61-71.
A unifold, mesofold, and superfold model of protein fold use.
Coulson AF, Moult J. pdf
Curr Opin Struct Biol. 2000 Jun;10(3):384-9.
From fold to function.
Moult J, Melamud E.pdf
Curr Opin Biotechnol. 1999 Dec;10(6):583-8.
Predicting protein three-dimensional structure.
Moult J.
Protein Folding
Protein Eng. 1998 Nov;11(11):991-7.
Determinants of side chain conformational preferences in protein
structures.
Samudrala R, Moult J.
J Mol Biol. 1998 May 29;279(1):287-302.
A graph-theoretic algorithm for comparative modeling of protein
structure.
Samudrala R, Moult J. pdf
Proteins. 1997;Suppl 1:179-84.
Ab initio protein folding simulations with genetic algorithms:
simulations on the complete sequence of small proteins.
Pedersen JT, Moult J.
J Mol Biol. 1998 Feb 6;275(5):895-916.
An all-atom distance-dependent conditional probability discriminatory
function for protein structure prediction.
pdf
Proteins. 1997 Dec;29(4):417-25.
Chaos in protein dynamics.
Braxenthaler M, Unger R, Auerbach D, Given JA, Moult J.
